Inquiry

mRNA Display-based Peptide Library Construction

The peptide library is a powerful tool in biological research, which can be used to screen a large number of peptides to find a few key bioactive peptides. It provides a reliable and effective platform for high-throughput drug screening and identification of protein interactions. CD BioSciences has accumulated rich experience in the field of peptide research. With the peptide discovery platform based on mRNA display technology, it can provide customers with peptide library construction services.

Introduction into mRNA Display Peptide Library

Peptide libraries are widely used in the rapidly developing proteomics and related fields, such as drug research and development, GPCR ligand screening, protein-protein interaction (PPI), protein function analysis, nucleic acid binding, enzyme substrate or inhibitor screening, antigen epitope screening, messenger molecule research and development, and peptide/protein signal answering, all of which require high-quality peptide libraries. The diversity peptide library generated by mRNA display technology can reach 10¹⁴ magnitude, which makes it possible to develop peptide inhibitors for targets that are difficult to target small molecules. With the maturity and development of biological display technology, the coding diversity library has become more convenient. Therefore, the rapid establishment of biological display peptide library as a drug discovery platform has gradually been recognized by the majority of pharmaceutical scientists.

Introduction of mRNA Display Peptide Library

Construction Process of mRNA Display Peptide Library

Obtain effective sequence information from natural peptides or design a random DNA library.
Prepare the elements needed to construct the mRNA display antibody library template, including T₇ promoter, translation enhancer, translation start codon and other sequences.
mRNA display peptide library was obtained by in vitro transcription and translation.
The mRNA/cDNA-peptide complex library was obtained by reverse transcription for further screening.

Our Services

mRNA display technology can build up to 10¹⁴ peptide libraries, which can be used for high-throughput screening of targeted cell epitopes, GPCR ligands, enzyme substrates, cell signals and other ligands. The experiment cycle is greatly shortened without the need for cell transformation and other steps. CD BioSciences, with its mature mRNA display peptide discovery platform, can provide the construction of small molecule random peptide libraries to promote drug discovery and basic research of customer.

We deliver a variety of modified peptide libraries for subsequent research, including but not limited to: biotin labeling, isotope labeling, PEG modification, methylation, acylation, acetylation, unnatural amino acid, cyclization, etc.
Our peptide library can be used to: drug research and development, GPCR ligand screening, protein-protein interaction research, protein function analysis, nucleic acid binding, enzyme substrate or inhibitor screening, antigen epitope screening, messenger molecule research and development, polypeptide and protein signal answering research, etc.

Workflow of Our Service

Our Workflow

Service Features

Accurate and fast experiment process, saving time for customers.
Professional technical experts accurately control the database building process.
The constructed library can screen a large number of different targets.
The peptide screened has high specificity and sensitivity.

CD BioSciences has many years of project development experience in peptide discovery. Based on the mRNA display technology platform, it can provide customers with various peptide library construction services. If you are interested in our services, please contact us for more details.

For Research Use Only. Not For Clinical Use.